The Month-to-month Researcher Highlight is our part highlighting the thrilling work of the UK Biobank Analysis Evaluation Platform person group. If you want to be featured, e mail group@dnanexus.com.
This was concurrently revealed within the July 2023 UK Biobank RAP E-newsletter. You’ll be able to join future installments right here.
This month’s Highlight options Professor Brian Browning, who develops strategies for analyzing large-scale genotype information. You can even view the recording of him discussing of his work on phasing UK Biobank information from earlier this yr.
Dr. Brian Browning
Professor of Drugs (Medical Genetics)
College of Washington
What are the main target and discovery highlights of your analysis?
I develop computational strategies for analyzing large-scale genotype and sequence information. One spotlight was work with Sharon Browning that confirmed there have been a minimum of two pulses of admixture between Denisovans and trendy people. One other spotlight was the event of genotype imputation strategies that cut back the price of genotype imputation to lower than a penny per genome.
What are among the key questions that you simply need to reply utilizing UK Biobank information?
Our group is fascinated by utilizing UKB information to seek for genomic loci which have undergone choice. We additionally use UKB information to develop new strategies for biobank-scale evaluation.
How has the UK Biobank Analysis Evaluation Platform (UKB-RAP) helped you carry out your analysis?
We automate our analyses with shell scripts and the UKB-RAP’s command line interface. The UKB-RAP’s net interface makes it simple to watch our compute jobs.
Any instruments or tutorials that you’ve got developed that might be helpful for the UKB-RAP group?
Our analysis group has developed a number of instruments for biobank-scale analyses. These embody a pipeline for phasing UK Biobank information, the Beagle software program package deal for genotype phasing and imputation, the hap-ibd program for IBD phase detection, and Ying Zhou’s IBDkin program for estimating kinship coefficients from IBD segments.
